The 40-year-old wrestler-turned-actor challenged The Undertaker to a fight but he was destroyed in quick fashion.
Cena went down after just one chokeslam and a tombstone piledriver.
The 16-time world champion responded to the shocking loss on Twitter later.
“I never knew he could play piano. That was amazing”
He shared a downbeat video on showing him looking drained and playing a sombre tune on the piano in a black-and-white font.
Cena did not comment further on the meaning behind the video.
But many people commented on it confused by the cryptic post.
One said: “What the hell is this?”
Another asked: “You OK?”
While others were just impressed by his piano skills.
A Twitter user wrote: “I have been watching John Cena since
And another posted: “Wow amazing! Man of many talents! God bless you!”
This week’s WrestleMania saw Ronda Rousey make her debut.
Cena has made fewer appearances on the wrestling show recently as he has been building a career in Hollywood.
He has starred in blockbuster films like Trainwreck, Ferdinand and Daddy’s Home 2.
He is also in comedy Blockers out which is in cinemas now.